Cytotoxic and Anti-infective Sesquiterpenes Present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae)
Planta MedDOI: 10.1055/s-0029-1240681AbstractA pharmacological screening of the ethanol extract and fractions of two Peruvian medicinal plants, and , led to the isolation and characterization of three 2,3-secoaromadendrane-type sesquiterpenoids, named plagiochiline A (), I (), and R (), as well as of two pseudoguaianolids, damsin () and confertin (), which exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds and were also investigated for their antileishmanial, trypanocidal, and antituberculosis activity against axenic amastigotes and trypomastigotes, as well as against MDR and sensitive strains of , respectively.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Med…
