Mice are in many ways similar to Homo sapiens on a fundamental level. That is why the law in this part of the world only permits scientists to conduct research on human embryonic stem cells when they have “clarified in advance” their specific questions by using animal cells as far as possible. However, such tests [...]
Chattopadhyay Subhasis, Chakraborty Nitya GIndian Journal of Human Genetics 2009 15(3):121-124Glucocorticoid-induced tumor necrosis factor receptor (TNFR) (GITR) family-related gene is a member of the TNFR super family. GITR works as one of the immunoregulatory molecule on CD4+ regulatory T cells and has an important role on cell survival or cell death in CD4+ T cells. [...]
ZO (zonula occludens) proteins are scaffolding proteins providing the structural basis for the assembly of multiprotein complexes at the cytoplasmic surface of intercellular junctions. In addition, they provide a link between the integral membrane proteins and the filamentous cytoskeleton. ZO proteins belong to the large family of membrane-associated guanylate kinase (MAGUK)-like proteins comprising a number [...]
I. Katanuma, K. Yagi, Y. Nakashima, M. Ichimura, and T. Imai The computer code by reduced magnetohydrodynamic equations were made which can simulate the flute interchange modes (similar to the RayleighTaylor instability) and the instability associated with the presence of nonuniform plasma flows (similar to the KelvinHelmholtz instability). This code is appli … [Phys. Plasmas [...]
Conclusion : The optimal management of patients at risk for ITGCN and future TGCT is still a matter of debate. Individualization of management, including biopsy and treatment, should be based on risk factors for TGCT, compliance with potential surveillance, and patient preferences particularly with regard to fertility. (Source: Indian Journal of Urology)
Gotto Geoffrey T, Carver Brett S, Sogani Pramod, Sheinfeld JoelIndian Journal of Urology 2010 26(1):90-95Recognition of the therapeutic role of retroperitoneal lymph node dissection (RPLND) in the setting of testicular germ cell tumors (GCTs) is of utmost importance. Although the histologic findings of RPLND provide diagnostic and prognostic information, the adequacy of initial RPLND is [...]
Alexander Emma J, White Ingrid M, Horwich AlanIndian Journal of Urology 2010 26(1):80-89Testicular germ cell tumors and, in particular, seminomas are exquisitely radiation and chemotherapy-sensitive and most presentations are highly curable. In recent years the management focus has been on reducing late sequelae of treatment. For Stage I disease surveillance and adjuvant carboplatin, chemotherapy has [...]
Conclusions : In patients with favorable disease based on IGCCCG criteria, clinical stage, STM, and radiographic evaluation are used to guide appropriate therapy to provide excellent long-term cure rates (>92%) in patients with metastatic NSGCT. (Source: Indian Journal of Urology)
Fitzgerald John P, Ercole Barbara, Parekh Dipen JIndian Journal of Urology 2010 26(1):64-67The basis of treatment for advanced germ cell tumors is chemotherapy and surgical resection of residual disease. Surgery has maintained its role in staging and therapeutic management. Despite these advances, much of the outcomes depend on proper patient selection. Complete removal of all [...]
Conclusions : CD4 progression continues two years after ART in patients who had base level > 100 cells. Early initiation of ART is necessary before CD4 crashing to < 100 cells for increasing the survival function. (Source: Journal of Postgraduate Medicine)
Conclusion : Approximately 90% (27 cases) were associated with poor prognostic factors in the present study according to the IELSG score. Perivascular reactive CD3 collar was seen in cases with low to intermediate IELSG score. A larger study is required to further validate that the presence of reactive perivascular CD3 collar is associated with good [...]
Horm Metab ResDOI: 10.1055/s-0030-1249035AbstractIt has been reported that the immunosuppressant rapamycin decreases the viability of pancreatic beta cells. In contrast, exendin-4, an analogue of glucagon-like peptide-1, has been found to inhibit beta cell death and to increase beta cell mass. We investigated the effects of exendin-4 on the cytotoxic effect of rapamycin in beta cells. [...]
Conclusion: This study suggests that glucocorticoid treatment reduces NO concentration in the MEE and may protect the ear from the SNHL caused by NO. (Source: International Journal of Pediatric Otorhinolaryngology)
By Jonathan Kraft, president of The Kraft Group and New England Patriots
As a long-time supporter of stem cell research, I’m proud to announce the launch of a new Children’s Hospital Boston Web site that we hope will demystify the science of stem cells and answer some of the public’s questions about them. For the past [...]
CONCLUSION: Some alcohol-dependent patients with megaloblastic anemia may respond to vitamin B12 treatment despite normal cobalamin serum levels; therefore in alcoholics caution is urged in the interpretation of these vitamin assays, because of possible functional vitamin B12 deficiency.
PMID: 20206879 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
MedWorm [...]
Singh Bhupendra P, Choubey Vimal K, Pandey RahulIndian Journal of Urology 2010 26(1):150-152 (Source: Indian Journal of Urology)
Beck Stephen D.WIndian Journal of Urology 2010 26(1):111-114Management of clinical stage I non seminomatous germ cell tumor includes surveillance, primary chemotherapy and retroperitoneal lymph node dissection. Stratifying clinical stage I disease to high- and low-risk groups for harboring micrometastic retroperitoneal disease (pathologic stage B) is based on pathologic characteristics of the primary tumor. The presence [...]
No survival advantage of autologous stem cell transplantation (ASCT) has been documented for patients older than 65 years, and in the era of thalidomide (Thalomid), bortezomib (Velcade), and lenalidomide (Revlimid), ASCT has a diminished role in the front-line treatment of older patients with myeloma. (Source: Cancer Network)
Conclusions: It was possible to conclude that bone repair was enhanced by the use of platelet- rich plasma in alveolar sockets. (Source: Table of Contents : Indian Journal of Dental Research : 2006 – 17(3))
Conclusions: A remarkable increase in capillary density was showed by videocapillaroscopic exam. The increased value of the density could be associated with angiogenesis mechanism and it could be an indicator of the evolutionary condition of LLP. Videocapillaroscopy may be useful for the evaluation of the evolution or regression of the disease. (Source: Table of Contents [...]