Scientists say they’ve discovered a genetic defect that may contribute to the development of as many as 1 in 4 cases of glioblastoma, the most common and aggressive type of brain tumor.
Highly active genes in leukemic stem cells linked to poor response to therapy, raised risk of death Source: HealthDay Related MedlinePlus Pages: Acute Myeloid Leukemia, Genes and Gene Therapy (Source: MedlinePlus Health News) MedWorm Sponsor Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
Transposons are mobile genetic elements that are an important source of genetic variation and are useful tools for genome engineering, mutagenesis screens, and vectors for transgenesis including gene therapy. We have used second-generation sequencing to analyze 2 x 105 unique de novo transposon insertion sites of the transposon Hermes in the Saccharomyces cerevisiae genome from [...]
Caucasian individuals with a variation at the rs2294008 polymorphism of the prostate stem cell antigen gene have an increased risk for developing non-cardia gastric cancer and its precursors, suggest study findings. (Source: MedWire News – Gastroenterology)
In the present paper, we have investigated early pathophysiological events in graft-versus-host disease (GVHD), a major complication to hematopoietic stem cell transplantation (HSCT). BLLB/c female mice conditioned with busulfan/cyclophosphamide (Bu-Cy) were transplanted with allogeneic male C57BL/6. Control group consisted of syngeneic transplanted Balb/c mice. In allogeneic settings, significant expansion and maturation of donor dendritic cells [...]
Authors: Andjelkovic T, Bankovic J, Stojsic J, Milinkovic V, Podolski-Renic A, Ruzdijic S, Tanic N The inactivation of p53 and PTEN tumor suppressor genes is a common genetic event in lung cancer. However, data on the effect of the joint inactivation of tumor-suppressor genes in non-small cell lung carcinoma (NSCLC) are lacking. The purpose of [...]
Authors: Cohen EP, Bruder ED, Cullinan WE, Ziegler D, Raff H Total body irradiation (TBI) or partial body irradiation is a distinct risk of accidental, wartime, or terrorist events. Total body irradiation is also used as conditioning therapy before hematopoietic stem cell transplantation. This therapy can result in injury to multiple tissues and might result [...]
Dear Health Conscious Reader, Do you take a multivitamin? The reason I’m asking you is that I’ve got some important evidence about what multivitamins do that even I didn’t know before now. Let me explain… Aging is something that begins on a cellular level. It starts with telomeres. They’re the timekeepers attached to every strand [...]
In the latest of a series of related papers, researchers at the University of California, San Diego School of Medicine, with colleagues in Austria and elsewhere, present a new and more definitive explanation of how fibrotic cells form, multiply and eventually destroy the human liver, resulting in cirrhosis. In doing so, the findings upend the [...]
Less-invasive robotic surgery for upper airway and digestive track malignant tumors is as effective as other minimally invasive surgical techniques based on patient function and survival, according to University of Alabama at Birmingham researchers. Head and neck squamous cell carcinomas account for about 4 percent of malignant tumors diagnosed in the United States each year. [...]
Agendia, a world leader in molecular cancer diagnostics, announced recently that together with several groups of scientific collaborators it has identified a major role for TSPYL5, one of its MammaPrint breast cancer prognosis genes, in the genesis of breast cancer. The study entitled: “TSPYL5 suppresses p53 levels and function by physical interaction with USP7″, was [...]
Source: National Institute of Child Health and Human Development – Related MedlinePlus Page: Intestinal Cancer (Source: MedlinePlus Health News)
(Cell Transplantation Center of Excellence for Aging and Brain Repair) In three monthly injections, researchers transplanted neurally committed, autologous cord blood derived cells tagged with iron oxide nanoparticles into the lateral cerebral ventricle of a 16-month-old child with severe global hypoxic ischemic brain injury. Using MRI tracking, they found that the tagged cells persisted in [...]
(Carnegie Mellon University) An international team of researchers led by Carnegie Mellon University’s Manojkumar Puthenveedu has discovered the mechanism by which signaling receptors recycle, a critical piece in understanding signaling receptor function. Writing in the journal Cell, the team for the first time describes how a signaling receptor travels back to the cell membrane after [...]
(Institut de recherches cliniques de Montreal) A team at the Institut de recherches cliniques de Montréal led by Dr. Tarik Möröy, president and scientific director of the institute and director of the hematopoiesis and cancer research unit, will be publishing an important breakthrough in tomorrow’s issue of Immunity, a scientific journal from the Cell Press [...]
G. Wolansky and A. Taflia Biological channels permeate ions through cell membranes. Ion channels carry a permanent charge that has a significant role in determining channel’s permeation properties such as selectivity to certain ions, current amplitude, etc. In this paper we deal with the determination of the permanent charge … [J. Chem. Phys. 133, 234113 [...]
Carrie Mowatt, Stephen M. Morris, Timothy D. Wilkinson, and Harry J. Coles In this letter, we demonstrate high slope efficiency laser emission from reflective liquid crystal laser devices with a silicon backplane. Three different cell architectures were fabricated and each resulting laser device was then characterized in terms of the excitation threshold and the slope [...]
Natalia Dubrovinskaia, Leonid Dubrovinsky, Razvan Caracas, and Michael Hanfland A pressure gauge is a key issue of any high pressure experiment in a diamond anvil cell (DAC). Here we present a method of in situ synthesis of microcrystals of diamond that can be further used as a pressure standard in the course of the same [...]
Potential links between metabolic derangements and adipose tissue (AT) inflammation in patients with chronic obstructive pulmonary disease (COPD) are unexplored. We investigated AT expressions of interleukin (IL)-6, tumor necrosis factor (TNF)-α, CD68 (macrophage cell surface receptor), caspase-3, and Bax, and their relationships to the metabolic phenotype in nine cachectic, 12 normal-weight, 12 overweight, and 11 [...]
Nature Reviews Clinical Oncology 8, 3 (2011). doi:10.1038/nrclinonc.2010.203 Author: Rebecca Kirk Although chronic lymphocytic leukemia (CLL) is often an indolent disease, high-risk cases have a dismal prognosis. The needs of this group of patients prompted a phase II trial to assess their outcome after treatment with reduced-intensity allogenic stem cell transplantation (RI allo-SCT).A total of [...]
