StemCells Therapy

Authors: C D Kaufman, R C Geiger & D A Dean (Source: Gene Therapy)

Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype Gene Therapy advance online publication, April 29, 2010. doi:10.1038/gt.2010.59 Authors: P Neeson, A Shin, K M Tainton, P Guru, H M Prince, S J Harrison, S Peinert, M J Smyth, J A Trapani, M H [...]

Authors: T Aoki, H Kataoka, M Nishimura, R Ishibashi, R Morishita & S Miyamoto (Source: Gene Therapy)

Authors: M A Trujillo, M J Oneal, S McDonough, R Qin & J C Morris (Source: Gene Therapy) MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly from thousands of authoritative health and news sources.

Authors: L Zhang, T-H Jia, A C M Chong, L Bai, H Yu, W Gong, P H Wooley & S-Y Yang (Source: Gene Therapy)

With near-identical DNA, why does one twin get the illness while the other does not? Source: HealthDay Related MedlinePlus Pages: Genes and Gene Therapy, Multiple Sclerosis (Source: MedlinePlus Health News)

Authors: Liu H, Chu Y, Lou G A fiber-modified adenovirus (rAd5F11B), loaded with the Kringle1-5 gene (rAd-K1-5) was used to infect human adipose tissue-derived mesenchymal stem cells (HAMSCs). At a multiplicity of infection of 20, the transfection efficiency in HAMSCs was 90% and the cell expansion and differentiation of infected HAMSCs were not significantly suppressed. [...]

Abstract  Antisense oligonucleotides (oligos) have been evaluated in both in vivo and in vitro prostate cancer models. Although most contain a single mRNA binding site, our laboratory has also evaluated bispecific types directed toward two proteins. This study evaluates the inhibition of in vitro propagating LNCaP cells employing mono- and bispecific oligos directed against bcl-2 [the [...]

Authors: Banerjee J, Hanson AJ, Nyren-Erickson EK, Ganguli B, Wagh A, Muhonen WW, Law B, Shabb JB, Srivastava DK, Mallik S A liposome-based amplified detection system is presented for the cancer cell secreted pathogenic enzyme matrix metalloproteinase-9 which does not require the use of biological antibodies. PMID: 20424776 [PubMed - in process] (Source: Chemical Communications)

(SAGE Publications UK) Although more than two fifths of lung cancers are diagnosed in patients over 70, data from clinical trials on the safest and most effective treatments for this age group are scarce. Now Italian oncologists are conducting a number of trials targeting elderly patients with non-small cell lung cancer, and offer a review [...]

(Institute of Physics) A new improved modeling system, developed by Chinese researchers, which attempts to incorporate more of the HIV virus’ random behavioral dynamics, suggests that a particular type of T cell could be useful in the development of an AIDS vaccine. (Source: EurekAlert! – Medicine and Health)

This article reviews the mechanisms of action as well as published and preliminary results of the Phase I – III clinical trials involving these novel immunosuppressive agents. PMID: 20420793 [PubMed - in process] (Source: Clinical Nephrology)

Source: National Institutes of Health – Related MedlinePlus Page: Stem Cells (Source: MedlinePlus Health News)

Authors: Schramm N, Pfluger T, Reiser MF, Berger F Panniculitis-like T-cell lymphoma is a very uncommon subtype of cutaneous T-cell lymphomas. In this case report, we describe the morphological (CT and MRI) and functional ((18)F-FDG-PET and bone scan) imaging findings in a 35-year-old patient who suffered from slowly progressing multiple subcutaneous lesions caused by this [...]

Pluristem Therapeutics Inc said on Tuesday its experimental stem cell treatment appeared to be safe and showed promise in treating critical limb ischemia, according to interim data from a small Phase I study. Reuters Health Information (Source: Medscape Medical News Headlines)

Depression is a debilitating but widespread condition involving low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. Nutrition may have the potential to affect a person’s risk of depression, its symptoms and its severity. The link is frequently explored in research studies, but the results are not yet conclusive. Some [...]

A volatile metabolic by-product can promote cell survival through the induction of autophagy. (Source: Signal Transduction Knowledge Environment)

The Johns Hopkins University School of Medicine and the New York Stem Cell Foundation (NYSCF) are establishing a collaborative program to advance the development and use of stem cells in therapies for a wide range of diseases, the organizations announced today. The program will train researchers to use stem cells and foster joint research projects. [...]

Endoscopy 2010; 42: 429-430DOI: 10.1055/s-0029-1244096© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Full text (Source: Endoscopy) MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly from thousands of authoritative health and news sources.

Planta MedDOI: 10.1055/s-0030-1249854AbstractTwo new holostane-type triterpene glycosides, named pentactasides I () and II (), and a new natural product, pentactaside III (), together with two known glycosides, philinopsides A () and B (), were isolated from the sea cucumber . Their structures were elucidated by extensive spectroscopic analysis and chemical evidences. Compounds and possess the [...]