StemCells Therapy

Authors: Wilkins T, Baird C, Pearson AN, Schade RR
Diverticular bleeding is a common cause of lower gastrointestinal hemorrhage. Patients typically present with massive and painless rectal hemorrhage. If bleeding is severe, initial resuscitative measures should include airway maintenance and oxygen supplementation, followed by measurement of hemoglobin and hematocrit levels, and blood [...]

We describe a case of invasive squamous cell carcinoma arising from actinic keratosis and causing orbital and intracranial invasion via perineural spread. Perineural invasion (PNI) is a known feature of SCC and very rarely basal cell carcinomas of the head and neck. A high degree of clinical suspicion is necessary to diagnose PNI. Varied clinical [...]

Authors: Mehta A, Chandra M
A 35-year-old lady presented with recurrent episodes of painful right upper lid swelling and ptosis of 6 months’ duration. The symptoms would subside with oral antibiotics and painkillers. She had also been undergoing treatment for 1 year for multiple painful osteolytic lesions in the long bones and [...]

CONCLUSIONS: A pedicled temporalis muscle flap and split thickness skin graft is a good one-stage reconstruction technique when faced with a large area of exposed bone. The temporalis muscle provides a suitable recipient site for a split skin graft and enhances its chances of survival. This technique, to our knowledge, had not previously been reported [...]

Authors: Engelhardt B
PMID: 19875629 [PubMed - in process] (Source: Journal of Leukocyte Biology)

A. Tarasenko and L. Jastrabik Magnetic nanoparticles have shown great promise for their use in many biomedical applications. Here we develop a quantifiable cell model to investigate particle diffusion. The tracer, jump, and chemical diffusion coefficients have been calculated for different densities of cytoskeleton proteins. … [Appl. Phys. Lett. 95, 173705 (2009)] published Fri Oct [...]

Statins, the most effective lipid-lowering drug class, reduce plasma cholesterol levels by reversibly inhibiting hepatic hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, the rate-controlling enzyme in cholesterol synthesis. Statins have pleiotropic effects that are unrelated to their lipid-lowering capability. They are immunomodulatory agents with neuroprotective qualities that have been studied in humans, animal models, and in cell [...]

CONCLUSIONS: This study showed that macrophages, B cells, and T cells occurred at different frequencies, localizations, and times after acute laser tympanic membrane perforation. Immunological cells were most prevalent in the proliferative mass adjacent to the annulus region. The cellular immunological response in freshly perforated eardrums was unexpectedly aggressive. OBJECTIVES: To study the occurrence of [...]

CONCLUSIONS: Human papilloma virus (HPV) was associated with sinonasal inverted papilloma (SIP) in 14/20 (70%) patients with a prevalence of HPV 6/11; alterations of the cell cycle proteins were statistically significant. OBJECTIVES: We investigated SIPs relationships between HPV infection and aberrant expression of cell cycle proteins. MATERIALS AND METHODS: Twenty SIPs were evaluated for p53, [...]

CONCLUSION: This study demonstrates morphological changes in the nasal mucosa as a consequence of functional changes of the nasal cavity after total laryngectomy (TLE). OBJECTIVE: Observation of the changes of the nasal mucosa in patients after TLE. PATIENTS AND METHODS: A cohort observational study contained 30 patients after TLE. These patients underwent nasal endoscopy and [...]

CONCLUSION: The 78th single nucleotide polymorphism (SNP) in exon 20 of epidermal growth factor receptor (EGFR) might be a predictor of the clinical course of squamous cell carcinoma of the head and neck (SCCHN), and genetic predisposition could influence the progression of SCCHN in Chinese subjects. OBJECTIVE: To analyze the clinical significance of EGFR SNP [...]

CONCLUSION: Extensive bone erosion correlated with a worse prognosis of the squamous cell carcinoma (SCC) of the temporal bone but extensive soft tissue involvement did not correlate with prognosis in this study. Resectability of the tumor seems to be major prognostic factor of temporal bone SCC. OBJECTIVE: Prognostic factors for SCC of the temporal bone [...]

Reporting in The Lancet, doctors found success in treating Leber’s congenital amaurosis, a rare type of blindness, with gene therapy. Study author Katherine High explains how injecting a gene-carrying virus into the eye has improved vision in a handful of patients.» E-Mail This     » Add to Del.icio.us (Source: NPR Health and Science)

MedWorm Message: Get the [...]

Authors: Liu YP, Berkhout B
RNA interference (RNAi) holds great promise as gene therapy approach against viral pathogens, including HIV-1. A specific anti-HIV-1 response can be induced via transfection of synthetic small interfering RNAs (siRNAs) or via intracellular transgene expression of short hairpin RNAs (shRNAs) or microRNAs (miRNAs). Both targeting of the [...]

Authors: Jafari M, Chen P
Applying RNA interference to silence a specific gene has opened a new and promising avenue of gene therapy. But a key bottleneck is the poor stability and inability of naked siRNA to translocate through cell membranes. Among several delivery systems, cationic peptides capable of penetrating cell membranes [...]

“Donated lungs that have to be discarded because they are not good enough for transplant can now be repaired and made suitable for patients,” The Times has reported.
The study behind the news looks at an experimental gene therapy technique that has been tested on pig and human lungs. Under this technique, a gene known as [...]

Correction of a defective gene is a promising approach for both basic research and clinical gene therapy. However, the absence of site-specific targeting and the low efficiency of homologous recombination in human cells present barriers to successful gene targeting. In an effort to overcome these barriers, we utilized triplex-forming oligonucleotides (TFOs) conjugated to a DNA [...]

Authors: J L Dembinski, E L Spaeth, J Fueyo, C Gomez-Manzano, M Studeny, M Andreeff
& F C Marini (Source: Cancer Gene Therapy)

Authors: R Zhang, L Ma, M Zheng, J Ren, T Wang, Y Meng, J Zhao, L Jia, L Yao, H Han, K Li
& A Yang (Source: Cancer Gene Therapy)

CONCLUSIONS. Ex vivo cell therapy and gene therapy have helped to expand our knowledge about plasticity and the mechanisms and factors that promote cell integration within the central nervous system. Although behavioural improvements have been reported in animal and human models, further work is still required on these studies to clear up a number of [...]