StemCells Therapy

ScienceDaily (Jan. 27, 2012) — A
collaborative anti-cancer research jointly conducted by The
Hong Kong Polytechnic University (PolyU), Peking University
Shenzhen Graduate School and Nevada Cancer Institute has led to
the development of a novel class of chemical inhibitors that
specifically target cancer cells with pluripotency.

This cutting-edge research has combined the effort of three
research teams including one led by Dr Tao Ye (??), Associate
Professor of PolyU's Department of Applied Biology and Chemical
Technology. This breakthrough may help the selective removal of
cancer stem cells and potentially provide a novel strategy to
eradicate cancers.

Cancer is a major cause of human death in China and all around
the world. It is difficult to treat cause of the existence of
cancer initiating cells/cancer stem cells. Although they exist
in very few in numbers, cancer stem cells (CSCs) can
proliferate and self-renew, and are pluripotent and
multipotent, which have the capability to differentiate into
various more heterogeneous cancer cells that constitute the
entire tumor mass. As stem cells, they are more resistant to
most conventional cancer therapies such as chemotherapy or
radiotherapy due to their differences in the cell cycle
regulation and DNA repair processes. They also act as the
source for metastasis and recurring drug resistant cancers
after conventional cancer therapy. Currently, there are no
chemical inhibitors or other agents that can specifically and
selectively target cancer stem cells. The development of
compounds that target cancer stem cells is an unmet medical
demand for the eradication of malignant cancers.

According to Dr Ye, the potential clinical applications of new
LSD1 inhibitors include the following:

(1) They can be used to treat malignant germ cell tumors such
as teratoma/teratocarcinomas, embryonic carcinomas, seminomas,
choriocarcinomas, and tumors of yolk sac. These tumors are
usually treated by surgery or cis-platinum, but after initial
treatment, these tumors always become resistant to platinum
drugs. So far, the LSD1 inhibitors are highly effective towards
these pluriptont cancers with stem cell properties.

(2) The LSD1 inhibitors may also be used to remove
teratomas/embryonic carcinomas during stem cell-based therapy.
One major problem in stem/iPS cell-based therapy is the
formation of embryonic carcinomas, teratomas, or
teratocarcinomas by incomplete differentiation of ES/iPS cells
in the organs of recipients.  Because LSD1 selectively
inhibit these pluripotent embryonic carcinomas, teratomas, or
teratocarcinomas, LSD1 inhibitors may help ensure the
successful application of stem cell-based therapy.

(3) More importantly, since teratomas/embryonic carcinomas are
pluripotent cancer stem cells, researchers will probe whether
cancer stem cells of other types of major organ-specific
cancers such as breast, ovarian, lung, and brain cancers are
sensitive to these LSD1 inhibitors. Further studies indicated
that LSD1 inhibitors can also be used to inhibit many cancer
stem cell-like cells such as breast and ovarian cancers.

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The above story is reprinted from materials provided by The Hong Kong Polytechnic
University, via ResearchSEA.

Note: Materials may be edited for content and length. For
further information, please contact the source cited
above.

Journal References:

Felix Cheung. Cancer biology: Ridding the seeds of
evil. Nature China, 2012; DOI: 10.1038/nchina.2012.1

J. Wang, F. Lu, Q. Ren, H. Sun, Z. Xu, R. Lan, Y. Liu, D.
Ward, J. Quan, T. Ye, H. Zhang. Novel Histone
Demethylase LSD1 Inhibitors Selectively Target Cancer Cells
with Pluripotent Stem Cell Properties. Cancer
Research, 2011; 71 (23): 7238 DOI: 10.1158/0008-5472.CAN-11-0896

Note: If no author is given, the source is cited
instead.

Disclaimer: This article is not intended
to provide medical advice, diagnosis or treatment. Views
expressed here do not necessarily reflect those of ScienceDaily
or its staff.

Read more here:
Collaborative research sheds light on new cancer stem cell therapies

For her, “that stuff” was a regimen of vitamins and
supplements, a high-fiber diet, and a series of
controlled-breathing exercises.

While a diagnosis is as elusive as ever, Sara says it has
sharply reduced her pain. “I can do anything now,” she says.
“I'm a lot happier.”

Her Jefferson pediatrician, Christina DiNicola, prescribed the
regimen after a 90-minute visit with Sara and her mother,
Michele. “After I interviewed her, I thought [the pain] was
emotional and hormonal,” said DiNicola. She kept Sara on an
anti-inflammatory drug prescribed by her doctor along with the
supplements regimen, and “the combination of all those things
did the trick.”

Integrative medicine is becoming more common in pediatrics,
said Lawrence Rosen, a pediatrician in Oradell, N.J., and chair
of the American Academy of Pediatrics Section on Complementary
and Integrative Medicine.

“The number of families with new babies interested in natural
and ecologically sustainable care is skyrocketing,” he says. “I
can tell that from my own practice.”

Still, those methods haven't made it into the mainstream.

Partly, this is an issue of time and money. The 90-minute visit
and 12-page questionnaire were keys to finding the right care,
DiNicola says, but insurance often doesn't cover visits that
long.

The Weinsteins paid out of pocket. Other integrative-pediatrics
programs are heavily subsidized by foundations, like those at
the Nemours/Alfred I. duPont Hospital for Children in
Wilmington.

Physicians practicing integrative medicine also face obstacles,
such as the refusal of Medicaid and most health plans to cover
many treatments. Results that meet evidence-based standards are
limited, and patients can improve for unknown reasons.

Integrative care in pediatrics faces its own set of problems:

Children are often less articulate about their symptoms.

The rest is here:
Alternatives for children

by Emily Gersema – Jan.
28, 2012 01:29 PM
The Republic | azcentral.com

A massive building near Phoenix Sky Harbor International
Airport is now home to a supercomputer that one day is expected
to store clinical-research reports, medical records and the
decoded genetic makeup of millions of patients and their
cancers.

Having this vault of medical information is a dream for
doctors, specialists and researchers who are trying to tailor
medical care to the individual needs of their cancer patients.
Despite huge advances in research and medicine, doctors have no
one-stop shop for up-to-date clinical-trial results, other
medical cases and genetic maps of their patients.

With access to this massive library, cancer doctors potentially
could specify with precision the dosages of medicines,
chemotherapy and radiation therapy for their patients by
comparing those cases to those of other patients with similar
genetic makeups and similar cancers.

In effect, this supercomputer could be a gateway to
personalized medical care, as its creator, billionaire
scientist Patrick Soon-Shiong, envisions it. His staff at CSS
Institute for Advanced Health in California, which owns the
project, and supporters of personalized medicine said the vault
also could help reduce doctor error in the diagnosis and
treatment of patients.

Better treatments and more accurate diagnoses could help lower
the cost of medical care and enable patients to get treatment
at home instead of at the hospital, they said.

The presence of the supercomputer could put Phoenix on the
cutting edge of medical research and treatment. The path to
these potential medical breakthroughs, however, is fraught with
privacy concerns. Patient advocates fear the project could open
a pathway to exploitation if patient information isn't
confidential. They want assurances that the institute would
require patient consent to obtain records, the records would be
kept private and the project would be under close regulatory
oversight.

The engine: A supercomputer

While the word “supercomputer” evokes an image of a giant
computer, the machine located in the Phoenix storage site
resembles a large herd of smaller computers that have been
linked to one another.

“It used to be a one big monolithic thing,” said Anoj Willy, of
the CSS Institute. “But now what we're able to do is take lots
of general-purpose computers and band them to create a big,
superprocessing engine.”

The CSS Institute project, which involves equipment and
products from Hewlett-Packard and Intel Corp., is in its
earliest stages, Willy said. The institute plans to focus data
collection on genetic research and cancer.

The endeavor would create at least 50 jobs with annual salaries
of about $75,000. Soon-Shiong also would invest at least $200
million in development, construction, machinery and equipment
to build the electronic-data-storage facility.

The institute is in the process of signing agreements with
various institutions that have been sequencing genomes — the
maps of DNA strands that make up living things.

Bob Peirce, senior vice president of Soon-Shiong's Nant
Holdings in Los Angeles, said that while scientists have made
strides in human genomic sequencing, the maps of these
sequences are scattered at different sites around the world,
depending on which institution decoded them.

Researchers have not yet decoded the whole human genome, Peirce
said. They have each decoded snippets.

The lack of a complete map and a one-stop shop for the genomic
information for doctors and researchers impedes their progress
in personalized medical treatment, he said.

This means genomic sequences currently aren't “relevant to the
average patient or the average doctor,” Peirce said.

Creating a complete map of the human genome would require a
massive, computerized data center, like the one being built by
Soon-Shiong in Phoenix — to decode what scientists estimate
are 3 billion pairs of DNA strands.

In addition, Soon-Shiong wants the supercomputer and its data
centers, including one planned for Scottsdale, to aid in
mapping the genetic makeup of individual patients' cancerous
cells.

“We need to be in a position where we can analyze the genome of
the cancer and determine the genome of the host patient (to
treat them),” Peirce said.

Peirce offered assurances that the data would be highly secured
to guard against hackers. The data could be accessed by people
who are deemed “authorized users,” he said, which could include
the patients themselves who are trying to monitor their
conditions and care. The institute has been working with a
“chief technical officer,” who worked at the Pentagon, on
securing the data centers and information they contain, Peirce
said. He declined to name the officer.

The concern: Privacy

Edward Abrahams, president of the Personalized Medicine
Coalition, a non-profit group in Washington, D.C., said
researchers are on the cusp of creating medical care tailored
to each person's needs, and they can reach that with a
supercomputer.

But they are faced with several challenges. Chief among them is
patient privacy, he said.

The federal Health Insurance Portability and Accountability Act
guards patient privacy, but its reach is limited. Patient
information is kept private within the realm of health care –
at the doctor's office, the hospital and with the patient's
insurance company, said Bob Gellman, a privacy expert in
Washington, D.C.

“An institution like this (CSS Institute) is not covered by
health-privacy laws,” Gellman said. “It's not a health-care
provider. It's not an insurer.”

Gellman said a worst-case scenario would involve a patient
sharing genetic information with a company or organization,
only to have it misused or exploited by another party.

“The information when it sat in the health-care system — when
it sat in your doctor's office — had all kinds of
protections,” Gellman said. “But if you give the information
with your consent to somebody else, then someone could just go
to that third party and say, 'Give me all your information.' ”

In that scenario, the records and data are out of the patient's
control and are unprotected.

Individuals trying to solve the health problems of their
autistic children, for example, may want to participate.

“That may be a perfectly rational decision.” Gellman said. “But
for people who don't know or aren't aware of that
(institution's) motivation … you might agree to give this
information, and 20 years later, you're in litigation with
somebody or you're applying for a job and it comes up.”

Excerpt from:
Medical-research cache in works

(PhysOrg.com) — Stem cells derived from fat have a surprising trick up their sleeves: Encouraged to develop on a stiff surface, they undergo a remarkable transformation toward becoming mature muscle cells. The new research appears in the journal Biomaterials. The new cells remain intact and fused together even when transferred to an extremely stiff, bone-like surface, which has University of …

Link:
Need muscle for a tough spot? Turn to fat stem cells

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Greenwich Hospital Embraces a Holistic Approach to Healthcare – January 23 is International Integrative Medicine Day

Many parents appreciate having alternatives to medication for their children who have Attention Deficit Disorder. This article tells how integrative pediatrics can help. It also offers resources to help find out more about this branch of pediatric medicine and alternative treatments for ADD.

More:
Integrative Pediatrics and ADD

Dr. Lisa Rankin and Dr. Martin Rukeyser of Life Chiropractic Center have merged their practices to form a new health care facility called Coastal Integrative Medicine, they announced in a news release.

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Two doctors form Coastal Integrative Medicine in Port St. Lucie

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Integrative medicine now available for pediatric patients at JMBCIM

For years it was thought that a difficult birth and other perinatal factors were the leading causes of cerebral palsy (CP), a group of disorders that can involve brain and nervous system functions such as movement, learning, hearing, seeing and thinking. Now, researchers suggest that the majority of cerebral palsy causes may in fact be caused by genetic abnormalities.

Read this article:
Genetic abnormalities may cause cerebral palsy, study suggests

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Genetic variation that raises risk of serious complication linked to osteoporosis drugs identified